Search | VHL CLAP/WR-PAHO/WHO

1.

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Parsons, Michael J; Brancaccio, Marco; Sethi, Siddharth; Maywood, Elizabeth S; Satija, Rahul; Edwards, Jessica K; Jagannath, Aarti; Couch, Yvonne; Finelli, Mattéa J; Smyllie, Nicola J; Esapa, Christopher; Butler, Rachel; Barnard, Alun R; Chesham, Johanna E; Saito, Shoko; Joynson, Greg; Wells, Sara; Foster, Russell G; Oliver, Peter L; Simon, Michelle M; Mallon, Ann-Marie; Hastings, Michael H; Nolan, Patrick M.

Cell ; 162(3): 607-21, 2015 Jul 30.

Article in English | MEDLINE | ID: mdl-26232227

2.

Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background.

Zhang, Cong; Shestopaloff, Konstantin; Hollis, Benjamin; Kwok, Chun Hei; Hon, Claudia; Hartmann, Nicole; Tian, Chengeng; Wozniak, Magdalena; Santos, Luis; West, Dominique; Gardiner, Stephen; Mallon, Ann-Marie; Readie, Aimee; Martin, Ruvie; Nichols, Thomas; Beste, Michael T; Zierer, Jonas; Ferrero, Enrico; Vandemeulebroecke, Marc; Jostins-Dean, Luke.

Am J Hum Genet ; 110(10): 1817-1824, 2023 10 05.

Article in English | MEDLINE | ID: mdl-37659414

3.

Multivariate phenotype analysis enables genome-wide inference of mammalian gene function.

Nicholson, George; Morgan, Hugh; Ganjgahi, Habib; Brown, Steve D M; Mallon, Ann-Marie; Holmes, Chris.

PLoS Biol ; 20(8): e3001723, 2022 08.

Article in English | MEDLINE | ID: mdl-35944064

4.

The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease.

Groza, Tudor; Gomez, Federico Lopez; Mashhadi, Hamed Haseli; Muñoz-Fuentes, Violeta; Gunes, Osman; Wilson, Robert; Cacheiro, Pilar; Frost, Anthony; Keskivali-Bond, Piia; Vardal, Bora; McCoy, Aaron; Cheng, Tsz Kwan; Santos, Luis; Wells, Sara; Smedley, Damian; Mallon, Ann-Marie; Parkinson, Helen.

Nucleic Acids Res ; 51(D1): D1038-D1045, 2023 01 06.

Article in English | MEDLINE | ID: mdl-36305825

5.

LAMA: automated image analysis for the developmental phenotyping of mouse embryos.

Horner, Neil R; Venkataraman, Shanmugasundaram; Armit, Chris; Casero, Ramón; Brown, James M; Wong, Michael D; van Eede, Matthijs C; Henkelman, R Mark; Johnson, Sara; Teboul, Lydia; Wells, Sara; Brown, Steve D; Westerberg, Henrik; Mallon, Ann-Marie.

Development ; 148(18)2021 03 24.

Article in English | MEDLINE | ID: mdl-33574040

6.

High-throughput mouse phenomics for characterizing mammalian gene function.

Brown, Steve D M; Holmes, Chris C; Mallon, Ann-Marie; Meehan, Terrence F; Smedley, Damian; Wells, Sara.

Nat Rev Genet ; 19(6): 357-370, 2018 06.

Article in English | MEDLINE | ID: mdl-29626206

7.

A framework for longitudinal latent factor modelling of treatment response in clinical trials with applications to Psoriatic Arthritis and Rheumatoid Arthritis.

Falck, Fabian; Zhu, Xuan; Ghalebikesabi, Sahra; Kormaksson, Matthias; Vandemeulebroecke, Marc; Zhang, Cong; Martin, Ruvie; Gardiner, Stephen; Kwok, Chun Hei; West, Dominique M; Santos, Luis; Tian, Chengeng; Pang, Yu; Readie, Aimee; Ligozio, Gregory; Gandhi, Kunal K; Nichols, Tom; Mallon, Ann-Marie; Kelly, Luke; Ohlssen, David; Nicholson, George.

J Biomed Inform ; : 104641, 2024 Apr 18.

Article in English | MEDLINE | ID: mdl-38642627

8.

Genic constraint against nonsynonymous variation across the mouse genome.

Powell, George; Simon, Michelle M; Pulit, Sara; Mallon, Ann-Marie; Lindgren, Cecilia M.

BMC Genomics ; 24(1): 562, 2023 Sep 22.

Article in English | MEDLINE | ID: mdl-37736706

9.

Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice.

Oestereicher, Manuela A; Wotton, Janine M; Ayabe, Shinya; Bou About, Ghina; Cheng, Tsz Kwan; Choi, Jae-Hoon; Clary, Dave; Dew, Emily M; Elfertak, Lahcen; Guimond, Alain; Haseli Mashhadi, Hamed; Heaney, Jason D; Kelsey, Lois; Keskivali-Bond, Piia; Lopez Gomez, Federico; Marschall, Susan; McFarland, Michael; Meziane, Hamid; Munoz Fuentes, Violeta; Nam, Ki-Hoan; Nichtová, Zuzana; Pimm, Dale; Bower, Lynette; Prochazka, Jan; Rozman, Jan; Santos, Luis; Stewart, Michelle; Tanaka, Nobuhiko; Ward, Christopher S; Willett, Amelia M E; Wilson, Robert; Braun, Robert E; Dickinson, Mary E; Flenniken, Ann M; Herault, Yann; Lloyd, K C Kent; Mallon, Ann-Marie; McKerlie, Colin; Murray, Stephen A; Nutter, Lauryl M J; Sedlacek, Radislav; Seong, Je Kyung; Sorg, Tania; Tamura, Masaru; Wells, Sara; Schneltzer, Elida; Fuchs, Helmut; Gailus-Durner, Valerie; Hrabe de Angelis, Martin; White, Jacqueline K.

Mamm Genome ; 34(2): 180-199, 2023 06.

Article in English | MEDLINE | ID: mdl-37294348

10.

High-throughput discovery of genetic determinants of circadian misalignment.

Zhang, Tao; Xie, Pancheng; Dong, Yingying; Liu, Zhiwei; Zhou, Fei; Pan, Dejing; Huang, Zhengyun; Zhai, Qiaocheng; Gu, Yue; Wu, Qingyu; Tanaka, Nobuhiko; Obata, Yuichi; Bradley, Allan; Lelliott, Christopher J; Nutter, Lauryl M J; McKerlie, Colin; Flenniken, Ann M; Champy, Marie-France; Sorg, Tania; Herault, Yann; Angelis, Martin Hrabe De; Durner, Valerie Gailus; Mallon, Ann-Marie; Brown, Steve D M; Meehan, Terry; Parkinson, Helen E; Smedley, Damian; Lloyd, K C Kent; Yan, Jun; Gao, Xiang; Seong, Je Kyung; Wang, Chi-Kuang Leo; Sedlacek, Radislav; Liu, Yi; Rozman, Jan; Yang, Ling; Xu, Ying.

PLoS Genet ; 16(1): e1008577, 2020 01.

Article in English | MEDLINE | ID: mdl-31929527

11.

Interoperability of statistical models in pandemic preparedness: principles and reality.

Nicholson, George; Blangiardo, Marta; Briers, Mark; Diggle, Peter J; Fjelde, Tor Erlend; Ge, Hong; Goudie, Robert J B; Jersakova, Radka; King, Ruairidh E; Lehmann, Brieuc C L; Mallon, Ann-Marie; Padellini, Tullia; Teh, Yee Whye; Holmes, Chris; Richardson, Sylvia.

Stat Sci ; 37(2): 183-206, 2022 May.

Article in English | MEDLINE | ID: mdl-35664221

12.

Modelling the genetic aetiology of complex disease: human-mouse conservation of noncoding features and disease-associated loci.

Powell, George; Long, Helen; Zolkiewski, Louisa; Dumbell, Rebecca; Mallon, Ann-Marie; Lindgren, Cecilia M; Simon, Michelle M.

Biol Lett ; 18(3): 20210630, 2022 03.

Article in English | MEDLINE | ID: mdl-35317627

13.

Advancing data science in drug development through an innovative computational framework for data sharing and statistical analysis.

Mallon, Ann-Marie; Häring, Dieter A; Dahlke, Frank; Aarden, Piet; Afyouni, Soroosh; Delbarre, Daniel; El Emam, Khaled; Ganjgahi, Habib; Gardiner, Stephen; Kwok, Chun Hei; West, Dominique M; Straiton, Ewan; Haemmerle, Sibylle; Huffman, Adam; Hofmann, Tom; Kelly, Luke J; Krusche, Peter; Laramee, Marie-Claude; Lheritier, Karine; Ligozio, Greg; Readie, Aimee; Santos, Luis; Nichols, Thomas E; Branson, Janice; Holmes, Chris.

BMC Med Res Methodol ; 21(1): 250, 2021 11 14.

Article in English | MEDLINE | ID: mdl-34773974

14.

A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease.

Sethi, Siddharth; Vorontsov, Ilya E; Kulakovskiy, Ivan V; Greenaway, Simon; Williams, John; Makeev, Vsevolod J; Brown, Steve D M; Simon, Michelle M; Mallon, Ann-Marie.

BMC Genomics ; 21(1): 754, 2020 Nov 02.

Article in English | MEDLINE | ID: mdl-33138777

15.

A bioimage informatics platform for high-throughput embryo phenotyping.

Brown, James M; Horner, Neil R; Lawson, Thomas N; Fiegel, Tanja; Greenaway, Simon; Morgan, Hugh; Ring, Natalie; Santos, Luis; Sneddon, Duncan; Teboul, Lydia; Vibert, Jennifer; Yaikhom, Gagarine; Westerberg, Henrik; Mallon, Ann-Marie.

Brief Bioinform ; 19(1): 41-51, 2018 01 01.

Article in English | MEDLINE | ID: mdl-27742664

16.

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.

Crompton, Michael; Purnell, Tom; Tyrer, Hayley E; Parker, Andrew; Ball, Greg; Hardisty-Hughes, Rachel E; Gale, Richard; Williams, Debbie; Dean, Charlotte H; Simon, Michelle M; Mallon, Ann-Marie; Wells, Sara; Bhutta, Mahmood F; Burton, Martin J; Tateossian, Hilda; Brown, Steve D M.

PLoS Genet ; 13(8): e1006969, 2017 Aug.

Article in English | MEDLINE | ID: mdl-28806779

17.

The digital revolution in phenotyping.

Oellrich, Anika; Collier, Nigel; Groza, Tudor; Rebholz-Schuhmann, Dietrich; Shah, Nigam; Bodenreider, Olivier; Boland, Mary Regina; Georgiev, Ivo; Liu, Hongfang; Livingston, Kevin; Luna, Augustin; Mallon, Ann-Marie; Manda, Prashanti; Robinson, Peter N; Rustici, Gabriella; Simon, Michelle; Wang, Liqin; Winnenburg, Rainer; Dumontier, Michel.

Brief Bioinform ; 17(5): 819-30, 2016 09.

Article in English | MEDLINE | ID: mdl-26420780

18.

Applying the ARRIVE Guidelines to an In Vivo Database.

Karp, Natasha A; Meehan, Terry F; Morgan, Hugh; Mason, Jeremy C; Blake, Andrew; Kurbatova, Natalja; Smedley, Damian; Jacobsen, Julius; Mott, Richard F; Iyer, Vivek; Matthews, Peter; Melvin, David G; Wells, Sara; Flenniken, Ann M; Masuya, Hiroshi; Wakana, Shigeharu; White, Jacqueline K; Lloyd, K C Kent; Reynolds, Corey L; Paylor, Richard; West, David B; Svenson, Karen L; Chesler, Elissa J; de Angelis, Martin Hrabe; Tocchini-Valentini, Glauco P; Sorg, Tania; Herault, Yann; Parkinson, Helen; Mallon, Ann-Marie; Brown, Steve D M.

PLoS Biol ; 13(5): e1002151, 2015 May.

Article in English | MEDLINE | ID: mdl-25992600

19.

The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation.

Muñoz-Fuentes, Violeta; Cacheiro, Pilar; Meehan, Terrence F; Aguilar-Pimentel, Juan Antonio; Brown, Steve D M; Flenniken, Ann M; Flicek, Paul; Galli, Antonella; Mashhadi, Hamed Haseli; Hrabe de Angelis, Martin; Kim, Jong Kyoung; Lloyd, K C Kent; McKerlie, Colin; Morgan, Hugh; Murray, Stephen A; Nutter, Lauryl M J; Reilly, Patrick T; Seavitt, John R; Seong, Je Kyung; Simon, Michelle; Wardle-Jones, Hannah; Mallon, Ann-Marie; Smedley, Damian; Parkinson, Helen E.

Conserv Genet ; 19(4): 995-1005, 2018.

Article in English | MEDLINE | ID: mdl-30100824

20.

Introduction to Mammalian Genome Special Issue: Mammalian Genetic Resources.

Brown, Steve D M; Nadeau, Joseph H; Wells, Sara; Mallon, Ann-Marie; Teboul, Lydia; Tuggle, Christopher K; Schook, Lawrence B.

Mamm Genome ; 33(1): 1-3, 2022 03.

Article in English | MEDLINE | ID: mdl-35044497

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Latin-American Center for Perinatology, Woman and Reproductive Health

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